The Bosnian Muslims and the Irish Perspective

The conflict in Bosnia-Herzegovina can be understood in multiple ways, however, the focus of this paper is to examine the perspective of Ireland on the Bosnian Muslims at different levels of society--ranging from the population to international level--from June 01, 1992 to January 31, 1996. Through an analysis of letters to the editor in The Irish Times, parliamentary debate transcripts, and the Barbara Sloan European Union Document Collection located at the University of Pittsburgh\u27s Hillman Library, I have been able to reveal how complex perspectives within a state on a particular issue can be, and how they can vary between states

Synthetic chemical inducers and genetic decoupling enable orthogonal control of the rhaBAD promoter

External control of gene expression is crucial in synthetic biology and biotechnology research and applications, and is commonly achieved using inducible promoter systems. The E. coli rhamnose-inducible rhaBAD promoter has properties superior to more commonly-used inducible expression systems, but is marred by transient expression caused by degradation of the native inducer, L-rhamnose. To address this problem, 35 analogs of L-rhamnose were screened for induction of the rhaBAD promoter, but no strong inducers were identified. In the native configuration, an inducer must bind and activate two transcriptional activators, RhaR and RhaS. Therefore, the expression system was reconfigured to decouple the rhaBAD promoter from the native rhaSR regulatory cascade so that candidate inducers need only activate the terminal transcription factor RhaS. Re-screening the 35 compounds using the modified rhaBAD expression system revealed several promising inducers. These were characterised further to determine the strength, kinetics and concentration-dependence of induction; whether the inducer was used as a carbon source by E. coli; and the modality (distribution) of induction among populations of cells. L-Mannose was found to be the most useful orthogonal inducer, providing an even greater range of induction than the native inducer Lrhamnose, and crucially, allowing sustained induction instead of transient induction. These findings address the key limitation of the rhaBAD expression system, and suggest it may now be the most suitable system for many applications

Mass Functions of Supermassive Black Holes Across Cosmic Time

The black hole mass function of supermassive black holes describes the evolution of the distribution of black hole mass. It is one of the primary empirical tools available for mapping the growth of supermassive black holes and for constraining theoretical models of their evolution. In this review we discuss methods for estimating the black hole mass function, including their advantages and disadvantages. We also review the results of using these methods for estimating the mass function of both active and inactive black holes. In addition, we review current theoretical models for the growth of supermassive black holes that predict the black hole mass function. We conclude with a discussion of directions for future research which will lead to improvement in both empirical and theoretical determinations of the mass function of supermassive black holes.Comment: 40 pages, 7 figures, review paper accepted for the Advances in Astronomy Special Issue "Seeking for the Leading Actor on the Cosmic Stage: Galaxies versus Supermassive Black Holes

Impact of an EHR-based tool on COPD Management in Primary Care

Background: GOLD (2017) guidelines provide evidence based recommendations for treating COPD, although their employment in clinical practice is inconsistent. Lack of a standardized method to view COPD specific information within the EHR during patient encounters complicates visits and development of GOLD-guided treatment plans. Our goal is to determine the impact of an EHR-based tool on relevant COPD disease measurements (spirometry rates, pneumococcal vaccination rates and COPD Action plans) Methods: An EHR-based tool (SmartPhrase) was developed and released to providers to facilitate GOLD(2017) guideline reference during patient encounters. Computer based instructional videos of GOLD (2017) guidelines and EHR-based tool were presented to providers prior to 90 day intervention. A two-pronged pre-and post-intervention analysis was carried out examining 1) subjective provider application of GOLD (2017) guidelines, and 2) objective inclusion of GOLD guidelines within the EHR patient encounter of COPD patients aged \u3e 18 at a rural Primary Care clinic. Results: Compared to pre-intervention, providers reported EHR-tool was rated as ‘likely’ to improve job performance and effectiveness when treating COPD patients (from 42.8% to 75%) and ‘likely’ to make documenting COPD-specific data easier (28.5% to 75%), increased tendency to order Spirometry (33.9%) and refer to Pulmonary Rehab more frequently (25%). Compared to pre-intervention, objective changes in spirometry rates increased 3.9%, vaccination rates for PCV13 and PPSV23 increased slightly (both 1.9%); there were no changes in number of COPD Action plans. Conclusions: Preliminary data suggests that an EHR-based tool is a potentially effective tool to increase awareness and application of GOLD guidelines in the treatment of COPD in Primary Care. Increased intervention period of 12 months may provide more insight into changes in treatment practices

Some methods for reducing wing drag and wing-Nacelle interference

Primary efforts directed toward drag reduction centered on the design of both supercritical and subcritical families of airfoils, the reduction of induced drag through the use of vortex diffusers, and the reduction of interference drag for executive-type aircraft

A six-coordinate aryl-germanium complex formed by the Kläui ligand

PhGeCl₃ reacts with Na{[OP(OEt)₂]₃CoCp} to give the six-coordinate complex PhCl₂Ge{[OP(OEt)₂]₃CoCp}, characterised spectroscopically and by an X-ray crystal structure determination which showed a firmly-attached tridentate ligand [Ge–O 1.973(2) Å]